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KMID : 0978920120130040209
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Korean Journal of Clinical Geriatrics
2012 Volume.13 No. 4 p.209 ~ p.214
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Association between High-Sensitivity C-Reactive Protein and Alzheimer’s Disease
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Wang Min-Jeong
Kim Young-Do
Cho Hyun-Ji
Song In-Uk
Chung Sung-Woo
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Abstract
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Background: High-sensitivity C-reactive protein (hs-CRP) is a sensitive systemic marker of inflammation, and increased levels of hs-CRP are associated with inflammatory reactions. Inflammation is believed to play a pivot role in cognitive decline, Alzheimer’s disease (AD), and vascular dementia. However, previous several studies have suggested weak relationship between hs-CRP and AD development, though a strong relationship with vascular dementia development. Therefore, we studied to clarify a role of hs-CRP in development and progression of AD.
Methods: We recruited 54 AD patients and 91 healthy controls. Venous blood samples for hs-CRP measurement were obtained from all subjects. All AD patients underwent neuropsychological tests for evaluating of diagnosis and progression of dementia. We analyzed correlation between hs-CRP and AD development as well as progression (severity) of cognitive decline.
Results: Serum hs-CRP levels in AD patients showed higher concentration than those in healthy controls. But we did not find significant association between hs-CRP and neuropsychological tests for evaluation of dementia severity. However, the odds ratio with a 95% confidence interval (CI) of the AD by hs-CRP was 2.455 (95% CI 1.779-3.386).
Conclusion: In this study, we could suggest that there are significant association between hs-CRP and AD and also assume that increased hs-CRP level could play a role in risk factor of AD development. However, hs-CRP as prognostic factor of progression was unclear because this study showed that there was no significant relationship between hs-CRP and progression of AD.
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KEYWORD
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Alzheimer’s disease, High-sensitivity C-reactive protein, Inflammation
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